Herein we report a dual-responsive doxorubicin–indoximod conjugate (DOXIND) for programmed chemoimmunotherapy. This conjugate is able to release doxorubicin and indoximod upon exposure to appropriate stimuli for synergistic chemotherapy and immunotherapy, respectively. We demonstrate its promoting effects on immune response and inhibiting effects on tumor growth through a series of in vitro and in vivo experiments.

中文翻译：

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用于程序化化学免疫疗法的双反应多柔比星-吲哚莫德偶联物

在这里，我们报告了一种用于程序化化学免疫疗法的双反应阿霉素-吲哚莫德偶联物 (DOXIND)。该偶联物能够在暴露于适当的刺激物时分别释放多柔比星和吲哚莫德，用于协同化学疗法和免疫疗法。我们通过一系列体外和体内实验证明了它对免疫反应的促进作用和对肿瘤生长的抑制作用。