BACKGROUND

Transient global amnesia (TGA) is an idiopathic acute neurological disorder that presents with sudden onset anterograde memory loss. It was first described as a syndrome in 1956 by Courjon and Guyotat¹ and also by Bender.² Fisher and Adams formally described TGA in 1964.³

The usual presentation is a patient between 50 and 70 years of age who is cognitively and neurologically intact but asking repetitive questions and unable to form new memories. Symptoms are short-lived and resolve within 24 h. The incidence has been reported as 23.5 per 100,000 people per year and is more common in people who get migraine headaches.^{4, 5}

TGA is often precipitated by physical or emotional stressors, pain, the Valsalva maneuver, hot or cold water immersion, or sexual intercourse.⁶ The criterion standard of TGA diagnosis combines seven clinical criteria: the attack is witnessed, there is clear anterograde amnesia, the absence of other neurological symptoms during the attack, the absence of abnormal neurological examination findings, memory loss is less than 24 h, there are no epileptic features or history of same, and there is no recent head injury.⁷ The workup of TGA can include laboratory testing, EEG, ECG, echocardiography, and advanced neuroimaging.

中文翻译：

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热门新闻：短暂性全球健忘症的 MRI 敏感性

背景

暂时性全面失忆症 (TGA) 是一种特发性急性神经系统疾病，表现为突然发作的顺行性记忆丧失。^{1956 年，Courjon 和 Guyotat 1}以及 Bender首次将其描述为一种综合征。^{2 Fisher 和 Adams 于 1964年}正式描述了 TGA。3

通常的表现是患者年龄在 50 至 70 岁之间，认知和神经功能完好，但重复提出问题，无法形成新的记忆。症状是短暂的，并在 24 小时内消退。据报道，每年每 100,000 人中有 23.5 人发病，并且在偏头痛患者中更为常见。^{4, 5}

TGA 通常由身体或情绪压力、疼痛、Valsalva 动作、热水或冷水浸泡或性交引起。⁶ TGA 诊断标准结合七项临床标准：有发作见证，有明显顺行性遗忘，发作时无其他神经系统症状，无异常神经系统检查发现，记忆丧失小于 24 h，有没有癫痫特征或相同病史，近期也没有头部受伤。⁷ TGA 的检查可包括实验室测试、EEG、ECG、超声心动图和高级神经影像学。