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Noma: A Neglected Area for Research
Journal of Dental Research ( IF 7.6 ) Pub Date : 2022-05-27 , DOI: 10.1177/00220345221100399
K U E Ogbureke 1
Affiliation  

Noma, a debilitating and destructive orofacial gangrene, remains endemic in the poor countries of sub-Saharan Africa and other noma hotbeds across the globe, mainly in countries characterized as underdeveloped economies with significant impoverished populations. Noma mostly affects children and infants. This is in spite of the universally held notion that noma is a preventable disease. Indeed, the current noma status quo has been cast as a human rights shortfall, since this devasting disease overwhelmingly affects children from poor countries. At the recently held Noma Research Day, a renewed call for the World Health Organization (WHO) to recognize and include noma as one of the neglected tropical diseases was accompanied by a recognition that research into all aspects of noma has waned or remained completely lacking—particularly that which addresses the basic science questions of the etiology, pathophysiology/pathobiology, and underlying mechanisms of the disease. Yet, a lack of incremental knowledge on the various aspects of noma continues to hamper our composite understanding of its biology. Without a fundamental understanding of the biology of noma, current preventive measures and treatment modalities will continue to fall short of the goals of prevention and eradication. This opinion piece draws renewed attention to the urgency of listing noma as a neglected tropical disease by the WHO. It also calls for major international research funding agencies, including the WHO and the National Institutes of Health, to renew their resolve to robustly fund structured, collaborative, and coordinated proposals that address questions on the epidemiology, etiology, pathophysiology/pathobiology, and molecular mechanisms of the disease. This is with a view to achieving more effective public health approaches toward prevention and to designing potential therapeutic regimens for early lesions. These steps are key to the ultimate eradication of noma.



中文翻译:

Noma:一个被忽视的研究领域

Noma 是一种使人衰弱且具有破坏性的口面部坏疽,在撒哈拉以南非洲的贫穷国家和全球其他 noma 温床中仍然流行,主要是在具有大量贫困人口的欠发达经济体的国家。Noma主要影响儿童和婴儿。尽管普遍认为 noma 是一种可预防的疾病,但这一观点仍然存在。事实上,目前的 noma 现状已被视为人权不足,因为这种毁灭性的疾病主要影响来自贫穷国家的儿童。在最近举行的 Noma 研究日上,再次呼吁世界卫生组织 (WHO) 承认并将 noma 列为被忽视的热带病之一,同时认识到对 noma 各个方面的研究已经减弱或仍然完全缺乏——特别是那些解决基本科学问题的研究疾病的病因、病理生理学/病理生物学和潜在机制。然而,缺乏对 noma 各个方面的增量知识继续阻碍我们对其生物学的综合理解。如果对 noma 的生物学有基本的了解,目前的预防措施和治疗方式将继续达不到预防和根除的目标。这篇评论文章再次引起了人们对世界卫生组织将 noma 列为被忽视的热带病的紧迫性的关注。它还呼吁主要的国际研究资助机构,包括世界卫生组织和美国国立卫生研究院,重新下定决心大力资助结构化、协作和协调的提案,以解决流行病学、病因学、病理生理学/病理生物学和分子机制方面的问题的疾病。这是为了实现更有效的公共卫生预防方法,并为早期病变设计潜在的治疗方案。这些步骤是最终根除 noma 的关键。和疾病的分子机制。这是为了实现更有效的公共卫生预防方法,并为早期病变设计潜在的治疗方案。这些步骤是最终根除 noma 的关键。和疾病的分子机制。这是为了实现更有效的公共卫生预防方法,并为早期病变设计潜在的治疗方案。这些步骤是最终根除 noma 的关键。

更新日期:2022-05-31
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