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Multiplexed imaging in oncology
Nature Biomedical Engineering ( IF 28.1 ) Pub Date : 2022-05-27 , DOI: 10.1038/s41551-022-00891-5
Chrysafis Andreou 1, 2, 3 , Ralph Weissleder 4, 5, 6 , Moritz F Kircher 7, 8, 9
Affiliation  

In oncology, technologies for clinical molecular imaging are used to diagnose patients, establish the efficacy of treatments and monitor the recurrence of disease. Multiplexed methods increase the number of disease-specific biomarkers that can be detected simultaneously, such as the overexpression of oncogenic proteins, aberrant metabolite uptake and anomalous blood perfusion. The quantitative localization of each biomarker could considerably increase the specificity and the accuracy of technologies for clinical molecular imaging to facilitate granular diagnoses, patient stratification and earlier assessments of the responses to administered therapeutics. In this Review, we discuss established techniques for multiplexed imaging and the most promising emerging multiplexing technologies applied to the imaging of isolated tissues and cells and to non-invasive whole-body imaging. We also highlight advances in radiology that have been made possible by multiplexed imaging.



中文翻译:

肿瘤学中的多重成像

在肿瘤学中,临床分子成像技术用于诊断患者、确定治疗效果和监测疾病复发。多重方法增加了可同时检测的疾病特异性生物标志物的数量,例如致癌蛋白的过度表达、异常代谢物摄取和异常血液灌注。每个生物标志物的定量定位可以显着提高临床分子成像技术的特异性和准确性,以促进精细诊断、患者分层和早期评估对给药治疗的反应。在这篇评论中,我们讨论了已建立的多重成像技术,以及应用于分离组织和细胞成像以及非侵入性全身成像的最有前途的新兴多重技术。我们还重点介绍了多重成像使放射学取得的进步。

更新日期:2022-05-27
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