Heart disease remains the leading cause of morbidity and mortality worldwide. With the advancement of modern technology, the role(s) of microtubules in the pathogenesis of heart disease has become increasingly apparent, though currently there are limited treatments targeting microtubule-relevant mechanisms. Here, we review the functions of microtubules in the cardiovascular system and their specific adaptive and pathological phenotypes in cardiac disorders. We further explore the use of microtubule-targeting drugs and highlight promising druggable therapeutic targets for the future treatment of heart diseases.

中文翻译：

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靶向微管治疗心脏病

心脏病仍然是全世界发病和死亡的主要原因。随着现代技术的进步，微管在心脏病发病机制中的作用越来越明显，尽管目前针对微管相关机制的治疗方法有限。在这里，我们回顾了微管在心血管系统中的功能及其在心脏疾病中的特定适应性和病理表型。我们进一步探索微管靶向药物的使用，并强调未来治疗心脏病的有前景的药物治疗靶点。