INTRODUCTION To determine the risk of inflammatory bowel disease (IBD) in patients with celiac disease (CeD) (and vice versa ) compared with general-population comparators. METHODS Using Swedish histopathology and healthcare register data, we identified 48,551 patients with CeD and 83,529 with IBD diagnosed in 1969-2016. Each patient was compared with age- and sex-matched general-population comparators (CeD: n = 240,136; IBD: n = 408,195). Cox regression estimated hazard ratios (HRs) for IBD in patients with CeD and vice versa . Our main analyses were limited to events beyond the first year of follow-up to reduce potential surveillance bias. RESULTS During follow-up, 784 (1.6%) patients with CeD were diagnosed with IBD compared with 1,015 (0.4%) matched comparators. In patients with CeD, the HR for IBD was 3.91 (95% confidence interval [CI] 3.56-4.31), with largely similar HRs for Crohn's disease (4.36; 3.72-5.11) and ulcerative colitis (3.40; 3.00-3.85). During follow-up, 644 (0.8%) patients with IBD and 597 (0.1%) comparators were diagnosed with CeD. The HR for CeD in patients with IBD was 5.49 (95% CI 4.90-6.16), with the highest risk estimates seen in ulcerative colitis (HR = 6.99; 6.07-8.05), and the HR for Crohn's disease was 3.31 (2.69-4.06). In patients with CeD and IBD, the diagnostic interval was usually <1 year; however, HRs of 3-4 were seen even after 10 years of follow-up. During 20 years of follow-up, 2.5% of patients with CeD developed incident IBD, and 1.3% of patients with IBD developed CeD. DISCUSSION The bidirectional association between CeD diagnosis and IBD warrants attention in the initial assessment and follow-up of these conditions. Their co-occurrence, independent of temporal sequence, suggests shared etiology.

中文翻译：

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腹腔疾病和炎症性肠病协会：一项全国范围内基于登记的队列研究。

引言 旨在确定与普通人群相比，乳糜泻 (CeD) 患者（反之亦然）患炎症性肠病 (IBD) 的风险。方法 使用瑞典组织病理学和医疗保健登记数据，我们确定了 1969-2016 年诊断出的 48,551 名 CeD 患者和 83,529 名 IBD 患者。将每位患者与年龄和性别匹配的一般人群比较者进行比较（CeD：n = 240,136；IBD：n = 408,195）。Cox 回归估计了 CeD 患者 IBD 的风险比 (HR)，反之亦然。我们的主要分析仅限于随访第一年之后的事件，以减少潜在的监测偏倚。结果 在随访期间，784 名 (1.6%) 的 CeD 患者被诊断为 IBD，而 1,015 名 (0.4%) 匹配的对照者。在 CeD 患者中，IBD 的 HR 为 3.91（95% 置信区间 [CI] 3. 56-4.31），克罗恩病（4.36；3.72-5.11）和溃疡性结肠炎（3.40；3.00-3.85）的 HR 大致相似。在随访期间，644 名 (0.8%) IBD 患者和 597 名 (0.1%) 对照者被诊断为 CeD。IBD 患者 CeD 的 HR 为 5.49（95% CI 4.90-6.16），溃疡性结肠炎的风险估计值最高（HR = 6.99；6.07-8.05），克罗恩病的 HR 为 3.31（2.69-4.06） ). 在 CeD 和 IBD 患者中，诊断间隔通常小于 1 年；然而，即使在 10 年的随访之后，仍然可以看到 3-4 的 HR。在 20 年的随访期间，2.5% 的 CeD 患者发生了 IBD，1.3% 的 IBD 患者发生了 CeD。讨论 CeD 诊断和 IBD 之间的双向关联值得在这些情况的初始评估和随访中引起注意。