当前位置: X-MOL 学术Burns Trauma › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice.
Burns & Trauma ( IF 5.3 ) Pub Date : 2022-05-21 , DOI: 10.1093/burnst/tkac014
Xiaotong Ding 1 , Qinghan Tang 1 , Zeyu Xu 1 , Ye Xu 2 , Hao Zhang 2 , Dongfeng Zheng 2 , Shuqin Wang 2 , Qian Tan 2 , Joanneke Maitz 3 , Peter K Maitz 3 , Shaoping Yin 1 , Yiwei Wang 1 , Jun Chen 1
Affiliation  

Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and mortality. The underlying mechanism of infections has been widely investigated by scientist, while standard wound management is routinely been used in general practice. However, strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization, delayed healing and drug resistance. In the present review, we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis, non-surgical methods and surgical methods. Moreover, we highlight emerging innovations in the development of antimicrobial peptides, phages, controlled drug delivery, wound dressing materials and herbal medicine, and find that sensitive diagnostics, combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection.

中文翻译:

治疗慢性和急性伤口感染的挑战和创新:从基础科学到临床实践。

急性和慢性伤口感染已成为全球主要的医疗保健负担,导致发病率和死亡率显着升高。科学家已广泛研究感染的潜在机制,而标准伤口管理通常用于一般实践。然而,由于生物膜定植、愈合延迟和耐药性的发生,伤口感染的诊断和治疗策略仍然是一个巨大的挑战。在本综述中,我们总结了在急慢性伤口感染中发现的常见微生物,并从临床诊断、非手术方法和手术方法等方面讨论了挑战。此外,我们强调了抗菌肽、噬菌体、受控药物递送、伤口敷料材料和草药开发方面的新兴创新,
更新日期:2022-05-21
down
wechat
bug