Traditional treatments such as chemotherapy and surgery usually cause severe side effects and excruciating pain. The emergence of nanomedicines and minimally invasive therapies (MITs) has brought hope to patients with malignant diseases. Especially, minimally invasive nanomedicines (MINs), which combine the advantages of nanomedicines and MITs, can effectively target pathological cells/tissues/organs to improve the bioavailability of drugs, minimize side effects and achieve painless treatment with a small incision or no incision, thereby acquiring good therapeutic effects. In this review, we provide a comprehensive review of the research status and challenges of MINs, which generally refers to the medical applications of nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging. Additionally, we also discuss their combined application in various fields including cancers, cardiovascular diseases, tissue engineering, neuro-functional diseases, and infectious diseases. The prospects, and potential bench-to-bedside translation of MINs are also presented in this review. We expect that this review can inspire the broad interest for a wide range of readers working in the fields of interdisciplinary subjects including (but not limited to) chemistry, nanomedicine, bioengineering, nanotechnology, materials science, pharmacology, and biomedicine.

中文翻译：

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微创纳米医学：光/超声/辐射/磁介导治疗和成像中的纳米技术

化疗和手术等传统治疗通常会引起严重的副作用和难以忍受的疼痛。纳米药物和微创疗法（MITs）的出现为恶性疾病患者带来了希望。特别是微创纳米药物（MINs），结合了纳米药物和MITs的优点，可以有效靶向病理细胞/组织/器官，提高药物的生物利用度，减少副作用，实现小切口或无切口无痛治疗，从而获得良好的治疗效果。在这篇综述中，我们对 MINs 的研究现状和挑战进行了全面的回顾，这通常是指纳米技术在光/超声/辐射/磁介导的治疗和成像中的医学应用。此外，我们还讨论了它们在癌症、心血管疾病、组织工程、神经功能疾病和传染病等各个领域的联合应用。本综述还介绍了 MIN 的前景和潜在的临床到临床转化。我们希望这篇评论能够激发在跨学科领域工作的广大读者的广泛兴趣，包括（但不限于）化学、纳米医学、生物工程、纳米技术、材料科学、药理学和生物医学。