Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease,Alzheimer's & Dementia

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Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2022-05-24 , DOI: 10.1002/alz.12684
Jonathan Vöglein _{1,

2} , Nicolai Franzmeier ₃ , John C Morris ₄ , Marianne Dieterich _{1,

2,

5,

6} , Eric McDade ₄ , Mikael Simons ₂ , Oliver Preische _{7,

8} , Anna Hofmann _{7,

8} , Jason Hassenstab ₄ , Tammie L Benzinger ₄ , Anne Fagan ₄ , James M Noble ₉ , Sarah B Berman ₁₀ , Neill R Graff-Radford ₁₁ , Bernardino Ghetti ₁₂ , Martin R Farlow ₁₂ , Jasmeer P Chhatwal ₁₃ , Stephen Salloway ₁₄ , Chengjie Xiong ₁₅ , Celeste M Karch ₄ , Nigel Cairns _{4,

16} , Richard J Perrin ₄ , Gregory Day ₁₁ , Ralph Martins ₁₇ , Raquel Sanchez-Valle ₁₈ , Hiroshi Mori ₁₉ , Hiroyuki Shimada ₁₉ , Takeshi Ikeuchi ₂₀ , Kazushi Suzuki ₂₁ , Peter R Schofield _{22,

23} , Colin L Masters ₂₄ , Alison Goate ₂₅ , Virginia Buckles ₄ , Nick C Fox ₂₆ , Patricio Chrem ₂₇ , Ricardo Allegri ₂₇ , John M Ringman ₂₈ , Igor Yakushev ₂₉ , Christoph Laske _{7,

30} , Mathias Jucker _{7,

8} , Günter Höglinger _{2,

5,

31} , Randall J Bateman ₄ , Adrian Danek _{1,

2} , Johannes Levin _{1,

2,

5} ,

Affiliation

Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Institute for Stroke and Dementia Research, Ludwig-Maximilians-Universität München, Munich, Germany.
Washington University School of Medicine, Saint Louis, Missouri, USA.
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
German Center for Vertigo and Balance Disorders, Ludwig-Maximilians-Universität München, Munich, Germany.
German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA.
University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Butler Hospital, Providence, Rhode Island, USA.
Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri, USA.
Medical School and Living Systems Institute, University of Exeter, Exeter, UK.
Edith Cowan University, Joondalup, Western Australia, Australia.
Service of Neurology, Hospital Clinic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.
Osaka City University Medical School, Abenoku, Osaka, Japan.
Brain Research Institute, Niigata University, Niigata, Japan.
University of Tokyo, Tokyo, Japan.
Neuroscience Research Australia, Sydney, Australia.
School of Medical Sciences, University of New South Wales, Sydney, Australia.
Florey Institute, University of Melbourne, Victoria, Australia.
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Dementia Research Centre, Institute of Neurology, University College London, London, UK.
FLENI, Buenos Aires, Argentina.
Center for the Health Professionals, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Department of Nuclear Medicine, Technical University of Munich, Munich, Germany.
Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany.

As knowledge about neurological examination findings in autosomal dominant Alzheimer disease (ADAD) is incomplete, we aimed to determine the frequency and significance of neurological examination findings in ADAD.

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