BACKGROUND. In human lupus nephritis (LN), tubulointerstitial inflammation (TII) on biopsy predicts progression to end-stage renal disease (ESRD). However, only about half of patients with moderate-to-severe TII develop ESRD. We hypothesized that this heterogeneity in outcome reflects different underlying inflammatory states. Therefore, we interrogated renal biopsies from LN longitudinal and cross-sectional cohorts.

中文翻译：

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特定的原位炎症状态与狼疮性肾炎肾功能衰竭的进展有关

背景。在人类狼疮性肾炎 (LN) 中，活检显示的肾小管间质炎症 (TII) 可预测进展为终末期肾病 (ESRD)。然而，只有大约一半的中重度 TII 患者发展为 ESRD。我们假设这种结果的异质性反映了不同的潜在炎症状态。因此，我们询问了来自 LN 纵向和横断面队列的肾活检。