The transmission pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 also called COVID-19 disease) in indoor environments are the main area of contention between health systems and scientists. In this context, little has been investigated about the collection of airborne viral shedding. Here, we collected air samples from 24 locations inside the sole COVID-19 patient care center in Zabol, Iran, for screening SARS-CoV-2 RNA from March to May 2021. Locations included the ICU, COVID-19 wards (CWs) rooms, corridors, nearby nurses’ stations, and toilets. We identified the SARS-CoV-2 RNA in breathing zone of CW, in room air, with the positivity rate of 2.5% at a concentration of 17 × 10³ virus genome copies/m³ air. It also investigates the relationship between local climate conditions [i.e., temperature and relative humidity] and COVID-19 transmission with the evolution of daily official data on the number of new cases, hospitalizations, and deaths. Current data explained that the difference of temperature and humidity may affect the behavior of virus along with other factors, i.e., population density, individual viral shedding, and infectious dose of SARS-CoV-2 (both indoor and outdoor). Our data support the potential SARS-CoV-2 airborne transmission indoors suggesting the specific safety assessment of building to improve ventilation solutions besides proper using face masks and extensive public health interventions.

严重急性呼吸系统综合症冠状病毒 2（SARS-CoV-2 也称为 COVID-19 病）在室内环境中的传播途径是卫生系统和科学家争论的主要领域。在这种情况下，很少有关于收集空气传播的病毒脱落的调查。在这里，我们从伊朗 Zabol 唯一的 COVID-19 患者护理中心内的 24 个地点收集了空气样本，用于从 2021 年 3 月至 2021 年 5 月筛查 SARS-CoV-2 RNA。地点包括 ICU、COVID-19 病房 (CW) 、走廊、附近的护士站和厕所。^{我们在 CW 的呼吸区、室内空气中鉴定出 SARS-CoV-2 RNA，在 17 × 10 3}病毒基因组拷贝/m ³的浓度下，阳性率为 2.5%空气。它还调查了当地气候条件 [即温度和相对湿度] 与 COVID-19 传播之间的关系，以及有关新病例、住院和死亡人数的每日官方数据的演变。目前的数据解释说，温度和湿度的差异可能会影响病毒的行为以及其他因素，即人口密度、个体病毒脱落和 SARS-CoV-2 的感染剂量（室内和室外）。我们的数据支持 SARS-CoV-2 可能在室内通过空气传播，这表明除了正确使用口罩和广泛的公共卫生干预措施之外，还需要对建筑物进行特定的安全评估，以改善通风解决方案。