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Low methacrylated poly(glycerol sebacate) for soft tissue engineering
Polymer Chemistry ( IF 4.6 ) Pub Date : 2022-05-23 , DOI: 10.1039/d2py00212d
Iris Cristina Becerril-Rodriguez , Frederik Claeyssens

Tissue engineering for soft tissue has made great advances in recent years, though there are still challenges to overcome. The main problem is that autologous tissue implants have not given good results since approximately 60% of tissue is lost or absorbed after implantation. The main strategy to overcome this issue has been the development of biomaterials capable of regenerating damaged tissue and mimicking the host environment. Biopolymers have been widely used for their biocompatibility and hydrophilicity, but they lack structural stability and mechanical properties suitable for the replacement of soft tissue. Synthetic polymers can overcome the drawbacks faced by biopolymers, with synthetic elastomers being of particular interest since they have mechanical properties and elastic moduli close to those of soft tissue. We focused on the physiochemical and biological characterization of poly(glycerol sebacate) methacrylate (PGS-M), and its application in the fabrication of scaffolds for soft tissue through the addition of methacrylate groups to improve its mechanical properties. PGS-M is a relatively new polymer that has not been widely used in soft tissue engineering. Our results confirm that its physicochemical characteristics make it a promising material for tissue engineering to fabricate scaffolds using various techniques like emulsion templating, 3D printing, and soft stereolithography.

中文翻译:

用于软组织工程的低甲基丙烯酸化聚癸二酸甘油酯

近年来,软组织的组织工程取得了长足的进步,但仍有挑战需要克服。主要问题是自体组织植入物没有产生良好的效果,因为大约 60% 的组织在植入后丢失或吸收。克服这个问题的主要策略是开发能够再生受损组织和模仿宿主环境的生物材料。生物聚合物因其生物相容性和亲水性而被广泛使用,但它们缺乏适合替代软组织的结构稳定性和机械性能。合成聚合物可以克服生物聚合物面临的缺点,其中合成弹性体特别受关注,因为它们具有接近软组织的机械性能和弹性模量。我们专注于聚(癸二酸甘油酯)甲基丙烯酸酯(PGS-M)的物理化学和生物学特性,以及通过添加甲基丙烯酸酯基团以改善其机械性能,将其应用于软组织支架的制造。PGS-M 是一种相对较新的聚合物,尚未广泛用于软组织工程。我们的研究结果证实,它的物理化学特性使其成为组织工程使用乳液模板、3D 打印和软立体光刻等各种技术制造支架的有前途的材料。PGS-M 是一种相对较新的聚合物,尚未广泛用于软组织工程。我们的研究结果证实,它的物理化学特性使其成为组织工程使用乳液模板、3D 打印和软立体光刻等各种技术制造支架的有前途的材料。PGS-M 是一种相对较新的聚合物,尚未广泛用于软组织工程。我们的研究结果证实,它的物理化学特性使其成为组织工程使用乳液模板、3D 打印和软立体光刻等各种技术制造支架的有前途的材料。
更新日期:2022-05-26
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