BACKGROUND Intracranial interventional embolization and intracranial clipping have been two typical therapies for the emergent rescue of intracranial aneurysm. However, there are still controversies over the impact of these two surgical treatments of aneurysms on cognitive and neurological functions of patients. METHODS A total of 144 patients with intracranial aneurysms were enrolled as the test subjects, who were randomly and evenly divided into the Intracranial Clipping group and the Interventional Embolization group. Cognitive and neurologic functions were evaluated by Glasgow Outcome Scale, Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE) scales, National Institutes of Health Stroke Scale (NIHSS) and Activities of Daily Living (ADL) scale. Enzyme-linked immunosorbent assay was used to analyze the serum levels of neuron-specific enolase (NSE) and S100β. RESULTS There were no significant differences in the preoperative MMSE, MoCA, NIHSS or ADL scale between two groups (p > 0.05). However, after operation, the MMSE and MoCA scores of the interventional embolization group were significantly higher, whereas the NIHSS and ADL scales were significantly lower than those of the intracranial clipping group (p < 0.05). The levels of NSE and S100β in the intracranial clipping group were significantly higher than in the interventional embolization group. CONCLUSION Intracranial interventional embolization exerts better effects on the cognitive and neurologic functions than intracranial clipping.

中文翻译：

---

颅内介入栓塞术和颅内夹闭术对颅内动脉瘤患者认知和神经功能的影响。

背景技术颅内介入栓塞术和颅内夹闭术是颅内动脉瘤急救抢救的两种典型疗法。然而，这两种动脉瘤手术治疗对患者认知和神经功能的影响仍存在争议。方法 144例颅内动脉瘤患者作为研究对象，随机分为颅内夹闭术组和介入栓塞组。通过格拉斯哥结果量表、蒙特利尔认知评估 (MoCA)、简易精神状态检查 (MMSE) 量表、美国国立卫生研究院卒中量表 (NIHSS) 和日常生活活动量表 (ADL) 评估认知和神经功能。酶联免疫吸附试验用于分析神经元特异性烯醇化酶（NSE）和S100β的血清水平。结果 两组的术前 MMSE、MoCA、NIHSS 或 ADL 量表无显着差异 (p > 0.05)。但术后，介入栓塞组的MMSE和MoCA评分显着高于颅内夹闭组，而NIHSS和ADL量表显着低于颅内夹闭组（p < 0.05）。颅内夹闭组NSE、S100β水平均显着高于介入栓塞组。结论颅内介入栓塞术对认知和神经功能的影响优于颅内夹闭术。结果 两组的术前 MMSE、MoCA、NIHSS 或 ADL 量表无显着差异 (p > 0.05)。但术后，介入栓塞组的MMSE和MoCA评分显着高于颅内夹闭组，而NIHSS和ADL量表显着低于颅内夹闭组（p < 0.05）。颅内夹闭组NSE、S100β水平均显着高于介入栓塞组。结论颅内介入栓塞术对认知和神经功能的影响优于颅内夹闭术。结果 两组的术前 MMSE、MoCA、NIHSS 或 ADL 量表无显着差异 (p > 0.05)。但术后，介入栓塞组的MMSE和MoCA评分显着高于颅内夹闭组，而NIHSS和ADL量表显着低于颅内夹闭组（p < 0.05）。颅内夹闭组NSE、S100β水平均显着高于介入栓塞组。结论颅内介入栓塞术对认知和神经功能的影响优于颅内夹闭术。而 NIHSS 和 ADL 量表显着低于颅内夹闭组 (p < 0.05)。颅内夹闭组NSE、S100β水平均显着高于介入栓塞组。结论颅内介入栓塞术对认知和神经功能的影响优于颅内夹闭术。而 NIHSS 和 ADL 量表显着低于颅内夹闭组 (p < 0.05)。颅内夹闭组NSE、S100β水平均显着高于介入栓塞组。结论颅内介入栓塞术对认知和神经功能的影响优于颅内夹闭术。