OBJECTIVE This study was designed to investigate the predictors of bronchopulmonary dysplasia in neonates with respiratory distress syndrome. METHODS This was a single-center retrospective cohort study conducted between 1 January 2015 and 31 December 2020. A total of 625 neonates with respiratory distress syndrome (RDS) were enrolled. Demographic data, clinical presentations, complications and related treatment information were collected and analyzed. We used bivariate and multivariate logistic-regression analyses to determine significant predictors of bronchopulmonary dysplasia (BPD) in RDS neonates. RESULTS In these 625 neonates, 102 (16.3%) of them developed BPD. Bivariate analysis and multivariate logistic-regression analyses revealed that birthweight, gestational age under 32 weeks, duration of oxygen therapy over 10 days, asphyxia, patent ductus arteriosus, transfusion of red blood cells (packed red blood cells) and surfactant use were significantly associated with the development of BPD. CONCLUSION Birthweight, gestational age <32 weeks, total duration of oxygen therapy >10 days, asphyxia, patent ductus arteriosus, need for red blood cell infusion, and the use of pulmonary surfactant were important predictors of BPD in neonates with RDS.

中文翻译：

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625 例呼吸窘迫综合征新生儿支气管肺发育不良的预测因子。

目的 本研究旨在调查呼吸窘迫综合征新生儿支气管肺发育不良的预测因素。方法 这是一项单中心回顾性队列研究，于 2015 年 1 月 1 日至 2020 年 12 月 31 日期间进行。共有 625 名呼吸窘迫综合征 (RDS) 新生儿入组。收集和分析人口统计学数据、临床表现、并发症和相关治疗信息。我们使用双变量和多变量逻辑回归分析来确定 RDS 新生儿支气管肺发育不良 (BPD) 的重要预测因子。结果 在这 625 名新生儿中，其中 102 名（16.3%）发生了 BPD。双变量分析和多变量逻辑回归分析显示，出生体重、胎龄低于 32 周、氧疗持续时间超过 10 天、窒息、动脉导管未闭、红细胞输血（浓缩红细胞）和表面活性剂的使用与 BPD 的发展显着相关。结论 出生体重、胎龄 <32 周、氧疗总持续时间 >10 天、窒息、动脉导管未闭、需要红细胞输注和使用肺表面活性物质是 RDS 新生儿 BPD 的重要预测因素。