The importance of noise exposure as a major environmental determinant of public health is being increasingly recognized. While in recent years a large body evidence has emerged linking environmental noise exposure mainly to cardiovascular disease, much less is known concerning the adverse health effects of noise on the brain and associated neuropsychiatric outcomes. Despite being a relatively new area of investigation, indeed, mounting research and conclusive evidence demonstrate that exposure to noise, primarily from traffic sources, may affect the central nervous system and brain, thereby contributing to an increased risk of neuropsychiatric disorders such as stroke, dementia and cognitive decline, neurodevelopmental disorders, depression, and anxiety disorder. On a mechanistic level, a significant number of studies suggest the involvement of reactive oxygen species/oxidative stress and inflammatory pathways, among others, to fundamentally drive the adverse brain health effects of noise exposure. This in-depth review on the cerebral consequences of environmental noise exposure aims to contribute to the associated research needs by evaluating current findings from human and animal studies. From a public health perspective, these findings may also help to reinforce efforts promoting adequate mitigation strategies and preventive measures to lower the societal consequences of unhealthy environments.

噪声暴露作为公共健康的主要环境决定因素的重要性日益得到认可。虽然近年来大量的身体证据表明环境噪声暴露主要与心血管疾病有关，但关于噪声对大脑的不良健康影响和相关的神经精神疾病结果知之甚少。尽管是一个相对较新的研究领域，但越来越多的研究和确凿的证据表明，暴露于主要来自交通源的噪音可能会影响中枢神经系统和大脑，从而导致中风、痴呆等神经精神疾病的风险增加和认知衰退、神经发育障碍、抑郁症和焦虑症。在机械层面上，大量研究表明，活性氧/氧化应激和炎症通路等从根本上推动了噪声暴露对大脑健康的不利影响。这篇关于环境噪声暴露对大脑后果的深入审查旨在通过评估人类和动物研究的当前发现来促进相关的研究需求。从公共卫生的角度来看，这些发现也可能有助于加强努力，促进适当的缓解战略和预防措施，以降低不健康环境的社会后果。这篇关于环境噪声暴露对大脑后果的深入审查旨在通过评估人类和动物研究的当前发现来促进相关的研究需求。从公共卫生的角度来看，这些发现也可能有助于加强努力，促进适当的缓解战略和预防措施，以降低不健康环境的社会后果。这篇关于环境噪声暴露对大脑后果的深入审查旨在通过评估人类和动物研究的当前发现来促进相关的研究需求。从公共卫生的角度来看，这些发现也可能有助于加强努力，促进适当的缓解战略和预防措施，以降低不健康环境的社会后果。