Three new compounds (1–3), were isolated from the 70%-EtOH extract of the roots of Datura metel L., along with thirty-six knowns (4–39). Their chemical structures were established based on extensive spectroscopic analyses, including HR-ESI-MS, ¹D NMR, and ²D NMR as well as comparison with the data reported in the literature. Compounds 7, 8, 10, 12, 14, 15, 19-23, 27, 29, 31, and 34 were isolated from Solanaceae for the first time and compounds 4, 5, 9, 17, 18, and 26 were firstly isolated from the genus Datura. Moreover, compounds 1, 5, 9, 12, 13, 17, 23, 24, 28, 37, and 39 showed potential anti-inflammatory activities (IC₅₀ <45 μM).

从曼陀罗根的 70%-EtOH 提取物中分离出三种新化合物 ( 1-3 )，以及 36 种已知化合物 ( 4-39 )。它们的化学结构是基于广泛的光谱分析建立的，包括 HR-ESI-MS、¹ D NMR 和² D NMR，以及与文献中报道的数据的比较。化合物7、8、10、12、14、15、19-23、27、29、31和34 _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _化合物4 , 5 , 9 , 17 , 18 , 26是首次从茄科植物中分离得到 , 化合物 4 , 5 , 9 , 18 , 26 是首次从曼陀罗属植物中分离得到. 此外，化合物1、5、9、12、13、17、23、24、28、37和39显示出潜在的抗炎_活性（IC 50 < 45 μM）。_ _ _ _ _