Longitudinal Trajectory of the Link Between Ventral Striatum and Depression in Adolescence,American Journal of Psychiatry

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Longitudinal Trajectory of the Link Between Ventral Striatum and Depression in Adolescence
American Journal of Psychiatry ( IF 17.7 ) Pub Date : 2022-05-18 , DOI: 10.1176/appi.ajp.20081180
Pedro Mario Pan ₁ , João R Sato ₁ , Marie-Laure Paillère Martinot ₁ , Jean-Luc Martinot ₁ , Eric Artiges ₁ , Jani Penttilä ₁ , Yvonne Grimmer ₁ , Betteke M van Noort ₁ , Andreas Becker ₁ , Tobias Banaschewski ₁ , Arun L W Bokde ₁ , Sylvane Desrivières ₁ , Herta Flor ₁ , Hugh Garavan ₁ , Bernd Ittermann ₁ , Frauke Nees ₁ , Dimitri Papadopoulos Orfanos ₁ , Luise Poustka ₁ , Juliane H Fröhner ₁ , Robert Whelan ₁ , Gunter Schumann ₁ , Margaret L Westwater ₁ , Christian Grillon ₁ , Hugo Cogo-Moreira ₁ , Argyris Stringaris ₁ , Monique Ernst ₁ , ₁

Affiliation

Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas, Universidade Federal de São Paulo, São Paulo, Brazil (Pan, Sato); National Institute of Developmental Psychiatry for Children and Adolescents, São Paulo, Brazil (Pan, Sato); Section on Neurobiology of Fear and Anxiety, NIMH, Bethesda, Md. (Pan, Westwater, Grillon, Ernst); Mathematics and Statistics Institute, Universidade Federal do ABC, Santo André, Brazil (Sato); Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales en psychiatrie," Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, Université Paris Cité, CNRS, Centre Borelli, Gif-sur-Yvette, France (Paillère Martinot, Martinot, Artiges); AP-HP Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris (Paillère Martinot); Department of Psychiatry, EPS Barthélemy Durand, Etampes, France (Artiges); Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic Kauppakatu 14, Lahti, Finland (Penttilä); Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (Grimmer, Banaschewski); MSB Medical School Berlin, Department of Psychology and Psychotherapy, Berlin (van Noort); Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, Germany (Becker); Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin (Bokde); Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology, and Neuroscience, SGDP Centre, King's College London (Desrivières, Poustka); Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, and Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany (Flor); Departments of Psychiatry and Psychology, University of Vermont, Burlington (Garavan); Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany (Ittermann); Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany (Nees); NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France (Papadopoulos Orfanos); Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany (Fröhner); School of Psychology and Global Brain Health Institute, Trinity College Dublin (Whelan); Center for Population Neuroscience and Stratified Medicine (PONS), ISTBI, Fudan University Shanghai, and Charité Mental Health, Berlin (Schumann); Department of Psychiatry, University of Cambridge, Herchel Smith Building, Addenbrooke's Hospital, Cambridge, U.K. (Westwater); Department of Education, ICT, and Learning, Østfold University College, Halden, Norway (Cogo-Moreira); Division of Psychiatry, University College London, and National and Kapodistrian University of Athens, Athens (Stringaris).

Objective:

Research in adolescent depression has found aberrant intrinsic functional connectivity (iFC) among the ventral striatum (VS) and several brain regions implicated in reward processing. The present study probes this question by taking advantage of the availability of data from a large youth cohort, the IMAGEN Consortium.

Methods:

iFC data from 303 adolescents (48% of them female) were used to examine associations of VS connectivity at baseline (at age 14) with depressive disorders at baseline and at 2-year (N=250) and 4-year (N=219) follow-ups. Eleven regions of interest, key nodes of the reward system, were used to probe the reward network and calculate the connectivity strength of the VS within this network (VS connectivity_rw). The main analyses assessed associations of VS connectivity_rw with depressive disorders, anhedonia, and low mood using logistic regression. Autoregressive models accounting for carryover effects over time were conducted to further evaluate these brain-behavior associations.

Results:

Higher right VS connectivity_rw was associated with higher probability of depressive disorders at baseline (odds ratio=2.65, 95% CI=1.40, 5.05). This finding was confirmed in the autoregressive model, adjusting for carryover effects of the depressive disorders across the three time points. VS connectivity_rw was not predictive of depressive disorders at follow-up assessments. Longitudinal associations between VS connectivity_rw and anhedonia emerged in the structural equation model: left VS connectivity_rw was associated with anhedonia at 2 years (odds ratio=2.20, 95% CI=1.54, 3.14), and right VS connectivity_rw was linked to anhedonia at 4 years (odds ratio=1.87, 95% CI=1.09, 3.21). VS connectivity_rw did not predict low mood at any time point in the structural equation model.

Conclusions:

The connectivity strength of the VS within the reward network showed distinct patterns of association with depressive disorders and anhedonia from mid to late adolescence, suggesting that the role of this circuitry in depression changes with age. This study replicates, in an independent sample, the association between the VS and depression previously reported in younger adolescents. The findings suggest a role of VS connectivity_rw in anhedonia but not in low mood.

中文翻译：

青春期腹侧纹状体与抑郁症之间联系的纵向轨迹

客观的：

对青少年抑郁症的研究发现腹侧纹状体 (VS) 和与奖励处理有关的几个大脑区域之间存在异常的内在功能连接 (iFC)。本研究利用来自大型青年群体 IMAGEN 联盟的可用数据来探讨这个问题。

方法：

来自 303 名青少年（其中 48% 为女性）的 iFC 数据用于检查基线（14 岁时）VS 连通性与基线、2 年（N=250）和 4 年（N=219）抑郁症的关联）跟进。十一个感兴趣的区域，即奖励系统的关键节点，用于探测奖励网络并计算该网络内 VS 的连接强度（VS 连接_rw）。主要分析使用逻辑回归评估了 VS 连通性_rw与抑郁症、快感缺乏和情绪低落的关联。进行了解释随时间推移的遗留效应的自回归模型，以进一步评估这些大脑行为关联。

结果：

较高的右侧 VS 连通性_rw与基线时抑郁症的较高概率相关（比值比 = 2.65, 95% CI = 1.40, 5.05）。这一发现在自回归模型中得到了证实，该模型针对三个时间点的抑郁症的遗留效应进行了调整。VS 连通性_rw不能预测后续评估中的抑郁症。VS 连通性_rw和快感缺失之间的纵向关联出现在结构方程模型中：左侧 VS 连通性_rw与 2 年时的快感缺失相关（比值比 = 2.20，95% CI = 1.54，3.14），右侧 VS 连通性_rw与快感缺失相关4 年（比值比=1.87，95% CI=1.09，3.21）。VS 连通性_rw没有预测结构方程模型中任何时间点的情绪低落。