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Auraptene ameliorates osteoporosis by inhibiting RANKL/NFATc1 pathway-mediated bone resorption based on network pharmacology and experimental evaluation.
Bone & Joint Research ( IF 4.6 ) Pub Date : 2022-5-18 , DOI: 10.1302/2046-3758.115.bjr-2021-0380.r1
Mi H Kim 1 , La Y Choi 1 , Jae Y Chung 1 , Eun-Jung Kim 2 , Woong M Yang 1
Affiliation  

The association of auraptene (AUR), a 7-geranyloxycoumarin, on osteoporosis and its potential pathway was predicted by network pharmacology and confirmed in experimental osteoporotic mice.

中文翻译:

基于网络药理学和实验评估,Auraptene 通过抑制 RANKL/NFATc1 通路介导的骨吸收来改善骨质疏松症。

通过网络药理学预测并在实验性骨质疏松小鼠中证实了 7-香叶氧基香豆素 auraptene (AUR) 与骨质疏松症及其潜在途径的关联。
更新日期:2022-05-18
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