We investigated the relationship between neutrophil–lymphocyte ratio (NLR) and restenosis in patients with femoropopliteal arterial disease following drug-coated balloon (DCB) angioplasty. Patients (n = 120) were divided into 3 groups according to the development of restenosis and the time of restenosis occurrence. The postoperative NLR was higher in the late-restenosis group than that in the no-restenosis group (3.53 vs 2.70; p = .011). In multivariate logistic analysis, postoperative NLR was an independent predictor of late restenosis (odds ratio: 1.404, 95% confidence interval: 1.073–1.839; p = .014). The postoperative NLR cutoff value for predicting late restenosis was 2.78 with a sensitivity of 80.8% and a specificity of 53.2% (area under the ROC curve was .666 (95% CI: .541–.791, p = .010). The incidence of late restenosis in the NLR ≥2.78 group was higher than that in the NLR <2.78 group (32.3 vs 9.1%; p = .002). Postoperative NLR is independently associated with late restenosis in patients treated with DCB for femoropopliteal arterial disease.

中文翻译：

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股腘动脉疾病患者中性粒细胞-淋巴细胞比值与药物涂层球囊再狭窄的关系

我们研究了药物涂层球囊 (DCB) 血管成形术后股腘动脉疾病患者中性粒细胞淋巴细胞比率 (NLR) 与再狭窄之间的关系。根据再狭窄的发展和再狭窄发生的时间将患者 (n = 120) 分为 3 组。晚期再狭窄组的术后 NLR 高于无再狭窄组（3.53 对 2.70；p = .011）。在多变量逻辑分析中，术后 NLR 是晚期再狭窄的独立预测因子（比值比：1.404，95% 置信区间：1.073–1.839；p=.014）。预测晚期再狭窄的术后 NLR 截断值为 2.78，敏感性为 80.8%，特异性为 53.2%（ROC 曲线下面积为 0.666（95% CI：0.541–0.791，p = 0.010））。 NLR ≥ 2.78 组的晚期再狭窄发生率高于 NLR <2.78 组（32.3 对 9.1%；p = .002）。术后 NLR 与接受 DCB 治疗的股腘动脉疾病患者的晚期再狭窄独立相关。