Titanium and its alloys are the most widely applied orthopedic and dental implant materials due to their high biocompatibility, superior corrosion resistance, and outstanding mechanical properties. However, the lack of superior osseointegration remains the main obstacle to successful implantation. Previous traditional surface modification methods of titanium-based implants cannot fully meet the clinical needs of osseointegration. The construction of local drug delivery systems (e.g., antimicrobial drug delivery systems, anti-bone resorption drug delivery systems, etc.) on titanium-based implants has been proved to be an effective strategy to improve osseointegration. Meanwhile, these drug delivery systems can also be combined with traditional surface modification methods, such as anodic oxidation, acid etching, surface coating technology, etc., to achieve desirable and enhanced osseointegration. In this paper, we review the research progress of different local drug delivery systems using titanium-based implants and provide a theoretical basis for further research on drug delivery systems to promote bone–implant integration in the future.

中文翻译：

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钛基植入物局部给药系统的构建以改善骨结合

钛及其合金具有高生物相容性、优异的耐腐蚀性和出色的机械性能，是应用最广泛的骨科和牙科植入材料。然而，缺乏优越的骨整合仍然是成功植入的主要障碍。以往传统的钛基种植体表面改性方法不能完全满足临床对骨结合的需求。在钛基种植体上构建局部给药系统（如抗菌给药系统、抗骨吸收给药系统等）已被证明是改善骨结合的有效策略。同时，这些给药系统还可以与传统的表面改性方法相结合，如阳极氧化、酸蚀、表面涂层技术等，以实现理想的和增强的骨整合。在本文中，我们回顾了使用钛基植入物的不同局部给药系统的研究进展，并为未来进一步研究促进骨-植入物整合的给药系统提供理论依据。