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Different Methods and Formulations of Drugs and Vaccines for Nasal Administration
Pharmaceutics ( IF 5.4 ) Pub Date : 2022-05-17 , DOI: 10.3390/pharmaceutics14051073
Junhu Tai 1 , Munsoo Han 1 , Dabin Lee 1 , Il-Ho Park 1 , Sang Hag Lee 1 , Tae Hoon Kim 1
Affiliation  

Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has some limitations, such as its low bioavailability due to metabolism on the mucosal surface, and irreversible damage to the nasal mucosa due to the ingredients added into the formula. Moreover, the method of nasal administration is not applicable to all drugs. The current review presents the nasal anatomy and mucosal environment for the nasal delivery of vaccines and drugs, as well as presents various methods for enhancing nasal absorption, and different drug carriers and delivery devices to improve nasal drug delivery. It also presents future prospects on the nasal drug delivery of vaccines and drugs.

中文翻译:

鼻用药物和疫苗的不同方法和配方

与其他给药途径相比,鼻给药具有优势,因为它避免了肝脏首过效应、血脑屏障穿透和肠胃外给药的依从性问题。然而,鼻腔给药也存在一些局限性,例如由于在黏膜表面代谢导致其生物利用度低,以及由于配方中添加的成分对鼻黏膜造成不可逆的损害。此外,经鼻给药的方法并非适用于所有药物。目前的综述介绍了疫苗和药物经鼻给药的鼻腔解剖学和黏膜环境,并介绍了增强鼻腔吸收的各种方法,以及改善鼻腔给药的不同药物载体和给药装置。
更新日期:2022-05-17
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