Hypoalbuminemia is associated with early morbidity and mortality in revision total knee arthroplasty. We evaluated the effect of preoperative hypoalbuminemia on 30-day morbidity and mortality in revision total hip arthroplasty (THA). The National Surgical Quality Improvement Program (NSQIP) database was queried from 2015 to 2018 to identify patients who underwent revision THA. Patients were stratified based on the presence or absence of preoperative hypoalbuminemia and their odds of a major complication or death within 30 days of revision THA with multivariate logistic regression. After Bonferroni correction for these 2 primary outcomes, statistical significance was defined as P<.025. A total of 2492 revision THAs with complete data were identified, of which 486 (20%) had preoperative hypoalbuminemia. Preoperative hypoalbuminemia increased the absolute risk of a major complication by 15.3% compared with patients with revision THA without hypoalbuminemia (30% vs 14.7%, P<.001). Patients with preoperative hypoalbuminemia also had nearly a 7-fold higher incidence of death (3.3%) compared with those with revision THA without preoperative hypoalbuminemia (0.5%, P<.001). After logistic regression, the odds of having a major complication after revision THA with preoperative hypoalbuminemia within 30 days were increased by 80% (odds ratio, 1.8; 95% CI, 1.4–2.3; P<.001), and the odds of death within 30 days were increased by 210% (odds ratio, 3.1; 95% CI, 1.2–7.8; P=.020). Hypoalbuminemia is associated with early morbidity and mortality after revision THA. [Orthopedics. 20XX;XX(X):xx–xx.]

低白蛋白血症与翻修全膝关节置换术的早期发病率和死亡率有关。我们评估了术前低白蛋白血症对翻修全髋关节置换术 (THA) 中 30 天发病率和死亡率的影响。从 2015 年到 2018 年，国家外科质量改进计划 (NSQIP) 数据库被查询，以确定接受翻修 THA 的患者。患者根据术前是否存在低白蛋白血症以及他们在翻修 THA 后 30 天内发生重大并发症或死亡的几率进行分层，并采用多变量逻辑回归。在对这 2 个主要结果进行 Bonferroni 校正后，统计学显着性定义为P<.025。共确定了 2492 例具有完整数据的翻修 THA，其中 486 例（20%）存在术前低白蛋白血症。与无低蛋白血症的翻修 THA 患者相比，术前低蛋白血症的主要并发症的绝对风险增加了 15.3%（30% 对 14.7%，P <.001）。与没有术前低蛋白血症的翻修 THA 患者（0.5%，P <.001）相比，术前低蛋白血症患者的死亡率（3.3%）高出近 7 倍。逻辑回归后，THA 翻修后 30 天内出现严重并发症的几率增加了 80%（优势比，1.8；95% CI，1.4-2.3；P<.001），30 天内死亡的几率增加了 210%（优势比，3.1；95% CI，1.2-7.8；P =.020）。低白蛋白血症与翻修 THA 后的早期发病率和死亡率有关。[骨科。20XX;XX(X):xx–xx.]