Sulfur dioxide (SO₂) derivatives are intertwined with many physiological and pathological processes in living systems, and excess intake of them are associated with various diseases. Herein, we have rationally constructed a novel colorimetric and far-red fluorescent probe for HSO₃⁻ based on a rhodamine analogue skeleton bearing a 3-quinolinium carboxaldehyde moiety. The novel probe exhibited a significant far-red fluorescence “Turn-on” response to HSO₃⁻, along with obvious color change from reddish to purple via the specific 1,4-nucleophilic addition reaction of HSO₃⁻ with the quinolinium moiety in 3-(4-(2-carboxyphenyl)-7-(diethylamino)chromenylium-2-yl)-1-methylquinolin-1-ium hypochlorite trifluoromethanesulfonate (AQCB). The AQCB had excellent water-solubility, and presented rapid response (<15 s), high sensibility (LOD = 49 nM) and selectivity toward HSO₃⁻. In addition, the probe was able to detect the content of HSO₃⁻ in food samples with satisfactory results. Furthermore, the probe possessed good cell membrane and could be successfully applied for imaging HSO₃⁻ in the mitochondria of living cells.

二氧化硫（SO ₂）衍生物与生命系统中的许多生理和病理过程交织在一起，过量摄入与各种疾病有关。在此，我们合理地构建了一种新型的HSO ₃ ^-比色和远红荧光探针，该探针基于带有3-喹啉甲醛部分的罗丹明类似物骨架。_{新型探针对HSO 3} -表现出显着的远红荧光“开启”响应，并通过HSO 3 _-^的特异性1,4-亲核加成反应从红色变为紫色^。与 3-(4-(2-羧基苯基)-7-(二乙氨基)铬烯鎓-2-基)-1-甲基喹啉-1-次氯酸三氟甲磺酸盐 ( AQCB)中的喹啉鎓部分。AQCB具有优异的水溶性，并呈现出快速响应（<15 s）、 高 灵敏度 （LOD = 49 nM）和对HSO ₃ ^-的选择性。此外，该探针能够检测食品样品中HSO ₃ ^{-的含量，结果令人满意。}此外，该探针具有良好的细胞膜，可成功应用于活细胞线粒体中的HSO ₃ ^-成像。