In this work, a new and simple carbon dots (CDs) based fluorescent probe was introduced for selective determination of diacerein (DIA) in presence of two co-formulated drugs. This highly fluorescent sensor was constructed using chitosan as a carbon and nitrogen source by single step carbonization. The constructed probe is based on the inner filter effect (IFE), in which DIA serves as a strong absorber, influencing the excitation of the fluorescer (CDs). This overlap leads to quenching of CDs fluorescence upon increasing DIA concentration within the range of 2.5–17.5 µg/mL with mean % recovery reached to 99.7 ± 0.7. The performance of the constructed sensor had been validated according to the ICH guidelines and the results revealed that it is precise and accurate. Moreover, it has many advantages such as simplicity, saving time and good selectivity for the determination of DIA as a minor component in presence of co-formulated drugs in its tablet dosage form.

在这项工作中，引入了一种新的、简单的基于碳点 (CDs) 的荧光探针，用于在两种共同配制的药物存在下选择性测定双醋瑞因 (DIA)。这种高荧光传感器是使用壳聚糖作为碳源和氮源通过一步碳化构建的。构建的探针基于内部过滤效应 (IFE)，其中 DIA 作为强吸收剂，影响荧光剂 (CD) 的激发。这种重叠导致 DIA 浓度在 2.5–17.5 µg/mL 范围内增加时 CDs 荧光猝灭，平均回收率达到 99.7 ± 0.7。所构建传感器的性能已根据 ICH 指南进行了验证，结果表明它是精确和准确的。此外，它还有很多优点，例如简单，