Many naturally occurring small peptides have significant therapeutic properties. Total synthesis of these peptides is not only helpful in the identification of their structures and providing methods to synthesize their analogues, but also contributes to their biosynthetic studies. As solid-phase synthesis simplifies the tedious and time-consuming isolation of intermediates, it has been widely applied in peptide synthesis. This review has highlighted the recent progress in solid-phase total synthesis of both linear and cyclic naturally occurring small peptides from 2014 to July 2021.

中文翻译：

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天然存在小肽的固相全合成研究进展

许多天然存在的小肽具有显着的治疗特性。这些肽的全合成不仅有助于识别它们的结构并提供合成它们的类似物的方法，而且有助于它们的生物合成研究。由于固相合成简化了繁琐且耗时的中间体分离，因此它已广泛应用于肽合成。这篇综述重点介绍了 2014 年至 2021 年 7 月在固相全合成线性和环状天然小肽方面的最新进展。