Abstract

Both radiation therapy and chemotherapy are efficient methods of cancer treatment. Efficiency of the hadron therapy is based on the phenomenon of the Bragg peak. Parameters of the Bragg peak such as its distance from the entrance point and maximum magnitude depend on kind of particles in the therapeutic beam and its energy, physical properties of target’s substance and its chemical composition. During chemotherapy and some time after it chemical composition of tissues may be changed so it may leads to changes of the Bragg peak parameters in the case of combined treatment. In the article results of study of the influence of the chemotherapy on the dose-depth distribution are presented. The computational models are proposed and different schemes of chemotherapy are considered for the proton and carbon ion beams.

中文翻译：

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水立方模型中化疗对布拉格峰参数的影响

摘要

放射疗法和化学疗法都是癌症治疗的有效方法。强子治疗的效率是基于布拉格峰的现象。布拉格峰与入口点的距离和最大幅度等参数取决于治疗光束中的粒子种类及其能量、目标物质的物理性质及其化学成分。在化疗期间和化疗后一段时间，组织的化学成分可能会发生变化，因此在联合治疗的情况下可能会导致布拉格峰参数的变化。本文介绍了化疗对剂量深度分布影响的研究结果。提出了计算模型，并为质子和碳离子束考虑了不同的化学疗法方案。