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Mimicry of silk utilizing synthetic polypeptides
Progress in Polymer Science ( IF 27.1 ) Pub Date : 2022-05-12 , DOI: 10.1016/j.progpolymsci.2022.101557
Nicholas J. Chan , Sarah Lentz , Paul A. Gurr , Thomas Scheibel , Greg G. Qiao

For thousands of years, ‘silk’ and silk-based materials have played an important role for mankind. Today, silk-based materials increasingly find use in novel application areas such as biomedical and advanced technologies. However, natural silks show limitations. To overcome these limitations, chemical polymerization methods have been developed that provide potential avenues to synthetic materials with silk-like features. This article summarizes the physicochemical properties of silks and reviews how the structure-property relationships of silks have inspired material design, for example, by integration of β-sheet forming polypeptide regions. Strategies that utilize N-carboxyanhydride ring-opening polymerization (NCA ROP) for polypeptide synthesis are the primary focus of this review as they provide a versatile platform for polypeptide engineering. Finally, the prospects of silk-inspired material design, such as amorphous polymers featuring β-sheet structures, for the design of high performance polymers are discussed.



中文翻译:

利用合成多肽模拟丝绸

几千年来,“丝”和以丝为基础的材料为人类发挥了重要作用。如今,丝基材料越来越多地用于新的应用领域,例如生物医学和先进技术。然而,天然丝绸显示出局限性。为了克服这些限制,已经开发出化学聚合方法,为具有丝状特征的合成材料提供了潜在途径。本文总结了丝的物理化学性质,并回顾了丝的结构-性质关系如何启发材料设计,例如,通过整合 β-折叠形成多肽区域。利用 N-羧酸酐开环聚合 (NCA ROP) 进行多肽合成的策略是本综述的主要焦点,因为它们为多肽工程提供了一个多功能平台。

更新日期:2022-05-12
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