AIMS Readmission is frequent among patients with cirrhosis and is a complex multifactorial process. To examine the association of alcohol use disorder (AUD) and risk of readmission in patients with alcohol-associated cirrhosis. METHODS AND RESULTS National Readmission Dataset (2016-2017) was used to extract a retrospective cohort of 53,348 patients with primary or secondary discharge diagnosis code of alcohol-associated cirrhosis with their first admission (26,674 patients with vs. propensity matched 26,674 without a primary or secondary discharge diagnosis code of AUD). Readmission within 30-day was lower (43.9 vs. 48%, P < 0.001) among patients identified to have AUD at the time of discharge. In a conditional logistic regression model, a diagnosis of AUD was associated with 15% reduced odds of 30-day readmission, 0.85 (0.83-0.88). Furthermore, the reason for readmission among patients identified vs. not identified to have AUD was less likely to be liver disease complication. The findings remained similar in a matched cohort of patients where the AUD diagnosis at discharge was listed as one of the secondary diagnoses only. CONCLUSION Although, our study findings suggest that identification of AUD at the time of discharge among patients hospitalized for alcohol-associated cirrhosis reduces the risk of 30-day readmission, unavailable information on patient counseling, referral for mental health specialist and treatment received for AUD limit the causality assessment. Future studies are needed overcoming the inherent limitations of the database to establish the role of identification and treatment of AUD in reducing readmission and liver decompensation in patients with alcohol-associated cirrhosis.

中文翻译：

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识别肝硬化患者的酒精使用障碍可降低 30 天再入院率。

AIMS 再入院在肝硬化患者中很常见，是一个复杂的多因素过程。旨在检查酒精使用障碍 (AUD) 与酒精相关性肝硬化患者再入院风险之间的关系。方法和结果 国家再入院数据集 (2016-2017) 用于提取 53,348 名首次入院时具有酒精相关性肝硬化主要或次要出院诊断代码的患者的回顾性队列（26,674 名患者与倾向匹配的 26,674 名没有主要或AUD二次出院诊断代码）。在出院时确定患有 AUD 的患者中，30 天内再入院率较低（43.9 对 48%，P < 0.001）。在条件逻辑回归模型中，AUD 的诊断与 30 天再入院几率降低 15% 相关，0.85 (0.83-0.88)。此外，确定患有 AUD 与未确定患有 AUD 的患者再次入院的原因不太可能是肝病并发症。在匹配的患者队列中，结果仍然相似，出院时 AUD 诊断仅被列为次要诊断之一。结论 虽然，我们的研究结果表明，在因酒精相关肝硬化住院的患者中出院时识别 AUD 可降低 30 天再入院、患者咨询信息不可用、心理健康专家转诊和接受 AUD 限制治疗的风险因果关系评估。