当前位置: X-MOL 学术Org. Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Pd-Catalyzed Asymmetric Allylic Substitution Cascade of Substituted 4-Hydroxy-2H-pyrones with meso-Allyl Dicarbonates
Organic Letters ( IF 5.2 ) Pub Date : 2022-05-11 , DOI: 10.1021/acs.orglett.2c00937
Yan Zheng 1 , Siqi Dong 1 , Kai Xu 2 , Delong Liu 1 , Wanbin Zhang 1, 2
Affiliation  

An efficient Pd-catalyzed asymmetric allylic substitution cascade of 4-hydroxy-2H-pyrones with meso-allyl dicarbonates has been developed for the synthesis of kinetic chiral tetrahydro-1H-pyrano[4,3-b]benzofuran-1-one products in ≤87% yield and ≤99% ee. The protocol was achieved via a temperature-controlled kinetic control process, which has been illustrated by means of the experimental results and control experiments. The reaction could be conducted on a gram scale, and the resulting product allows for several transformations.

中文翻译:

Pd催化的不对称烯丙基取代级联取代4-羟基-2H-吡喃酮与内消旋烯丙基二碳酸酯

开发了一种高效的 Pd 催化不对称烯丙基取代级联 4-羟基-2 H-吡喃酮与内消旋-烯丙基二碳酸酯合成动力学手性四氢-1 H-吡喃并[4,3 - b ]苯并呋喃-1-酮产品产率≤87%,ee≤99%。该协议是通过温度控制的动力学控制过程实现的,这已通过实验结果和控制实验进行了说明。该反应可以以克级进行,所得产物允许进行多种转化。
更新日期:2022-05-11
down
wechat
bug