BACKGROUND Brazil has one of the highest numbers of births with sickle-cell disease (SCD) in the Americas. Despite the risk of severe illnesses and death due to both vaccine-preventable infections, vaccination uptake in pediatric patients with SCD is unknown. MATERIAL AND METHODS Children under 18 years with SCD presenting to routine medical consultations had their vaccination status evaluated according to the national recommendations. Data obtained were classified as 'Adequate', 'Delayed' or 'Missing' vaccination and compared among age groups. RESULTS From 117 children screened, 100 had their vaccination card available. Vaccination coverage of routine vaccines was above 95% for all primary series and both age groups, with varied rates of delays and low missing doses. Among SCD extended vaccination, the most frequently delayed and missed vaccines were those specifically recommended to individuals with SCD as per national guidelines-and particularly those against encapsulated bacteria. Significant and varied rates of missing doses occurred in primary series and booster doses for PPSV23, Hib, menC, hepatitis A and varicella. The average influenza vaccination rate was 69.5%, with higher rates among younger children. CONCLUSIONS Children with SCD have alarming under-vaccination rates. Basic prevention strategies in Brazil should be reassessed in this specific population.

中文翻译：

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患有镰状细胞病的儿科患者的疫苗接种：摄取报告和小型回顾。

背景 巴西是美洲镰状细胞病 (SCD) 新生儿数量最多的国家之一。尽管疫苗可预防的感染都存在严重疾病和死亡的风险，但儿童 SCD 患者的疫苗接种情况尚不清楚。材料和方法 18 岁以下的 SCD 患儿接受常规医疗咨询，根据国家建议评估其疫苗接种状况。获得的数据被分类为“充分”、“延迟”或“缺失”疫苗接种，并在年龄组之间进行比较。结果 从 117 名接受筛查的儿童中，有 100 名获得了疫苗接种卡。对于所有初级系列和两个年龄组，常规疫苗的接种覆盖率均高于 95%，延迟率不同，缺失剂量低。在 SCD 延长疫苗接种中，最常被延迟和错过的疫苗是根据国家指南特别推荐给 SCD 患者的疫苗，尤其是针对包膜细菌的疫苗。在 PPSV23、Hib、menC、甲型肝炎和水痘的主要系列和加强剂量中出现了显着和不同的剂量缺失率。平均流感疫苗接种率为 69.5%，年幼儿童的接种率较高。结论 SCD 儿童的疫苗接种不足率令人担忧。应针对这一特定人群重新评估巴西的基本预防策略。甲型肝炎和水痘。平均流感疫苗接种率为 69.5%，年幼儿童的接种率较高。结论 SCD 儿童的疫苗接种不足率令人担忧。应针对这一特定人群重新评估巴西的基本预防策略。甲型肝炎和水痘。平均流感疫苗接种率为 69.5%，年幼儿童的接种率较高。结论 SCD 儿童的疫苗接种不足率令人担忧。应针对这一特定人群重新评估巴西的基本预防策略。