Polyphenolic materials are a class of fascinating and versatile bioinspired materials for biointerfacial engineering. In particular, due to the presence of active chemical groups, a series of unique physicochemical properties become accessible and tunable of the as-prepared polyphenolic platforms, which could delicately regulate the cell activities via cell–material contact-dependent interactions. More interestingly, polyphenols could also affect the cell behaviors via cell–material contact-independent manner, which arise due to their intrinsically functional characteristics (e.g., antioxidant and photothermal behaviors). As such, a comprehensive understanding on the relationship between material properties and desired biomedical applications, as well as the underlying mechanism at the cellular and molecular level would provide material design principles and accelerate the lab-to-clinic translation of polyphenolic platforms. In this review, we firstly give a brief overview of cell hallmarks governed by surrounding cues, followed by the introduction of polyphenolic material engineering strategies. Subsequently, a detailed discussion on cell–polyphenols contact-dependent interfacial interaction and contact-independent interaction was also carefully provided. Lastly, their biomedical applications were elaborated. We believe that this review could provide guidances for the rational material design of multifunctional polyphenols and extend their application window.

中文翻译：

---

调节细胞生物学的多功能多酚平台

多酚材料是一类用于生物界面工程的引人入胜且用途广泛的仿生材料。特别是，由于活性化学基团的存在，一系列独特的物理化学性质变得易于使用和调节所制备的多酚平台，这可以通过细胞-材料接触依赖性相互作用精细地调节细胞活动。更有趣的是，多酚还可以通过与细胞-材料接触无关的方式影响细胞行为，这是由于其固有的功能特性（例如，抗氧化和光热行为）。因此，全面了解材料特性与所需生物医学应用之间的关系以及细胞和分子水平的潜在机制将提供材料设计原则并加速多酚平台从实验室到临床的转化。在这篇综述中，我们首先简要概述了受周围线索支配的细胞标志，然后介绍了多酚材料工程策略。随后，还仔细讨论了细胞-多酚依赖于接触的界面相互作用和不依赖于接触的相互作用。最后，详细阐述了它们的生物医学应用。