Anosmia, or loss of smell, is strongly associated with SARS-CoV-2 infection in humans, but the underlying mechanism remains obscure. In a recent Cell study, Zazhytska et al. (2022) report non-cell-autonomous disruption of long-range genomic interactions of olfactory receptor genes in response to SARS-CoV-2 infection, and these interactions remain disrupted long after virus clearance.

中文翻译：

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闻不到病毒：SARS-CoV-2、染色质组织和嗅觉缺失

嗅觉丧失或嗅觉丧失与人类感染 SARS-CoV-2 密切相关，但其潜在机制仍不清楚。在最近的一项细胞研究中，Zazhytska 等人。(2022) 报告了响应 SARS-CoV-2 感染的嗅觉受体基因远程基因组相互作用的非细胞自主破坏，并且这些相互作用在病毒清除后很长一段时间内仍然受到破坏。