In this issue of Cancer Cell, Anadon et al. perform a multi-omics analysis of ovarian tumor infiltrating tissue-resident memory T (TRM) cells at the single-cell level that supports a differentiation model from CD103⁻TCF1⁺ re-circulating T-cell precursors driven by tumor antigen recognition. CD103⁺ TRM cells play a dominant anti-tumor role in ovarian cancer.

中文翻译：

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记忆 CD8+ T 细胞的组织驻留对于卵巢癌免疫原性的形成至关重要

在本期《癌细胞》中，Anadon 等人。在单细胞水平上对卵巢肿瘤浸润组织驻留记忆 T (TRM) 细胞进行多组学分析，支持由肿瘤抗原识别驱动的 CD103 – TCF1 + 再循环 T 细胞前体^的分化^模型。CD103 ⁺ TRM细胞在卵巢癌中发挥显着的抗肿瘤作用。