The introduction of stereogenic centers in supramolecular building blocks is used to unveil subtle changes in supramolecular structure and dynamics over time. Three stereogenic centers based on deuterium atoms were introduced in the side chains of a benzene-1,3,5-tricarboxamide (BTA) resulting in a supramolecular polymer in water that at first glance has a structure and dynamics identical to its achiral counterpart. Using three different techniques, the properties of the double helical polymers are compared after 1 day and 4 weeks. An increase in helical preference is observed over time as well as a decrease in the helical pitch and monomer exchange dynamics. It is proposed that the polymer of the chiral monomer needs time to arrive at its maximal preference in helical bias. These results indicate that the order and tight packing increase over time, while the dynamics of this supramolecular polymer decrease over time, an effect that is typically overlooked but unveiled by the isotopic chirality.

中文翻译：

---

超分子聚合物的结构和动力学：观望

在超分子结构单元中引入立体中心用于揭示超分子结构和动力学随时间的细微变化。在苯-1,3,5-三甲酰胺 (BTA) 的侧链中引入了三个基于氘原子的立体中心，从而在水中产生了一种超分子聚合物，乍一看其结构和动力学与其非手性对应物相同。使用三种不同的技术，在 1 天和 4 周后比较双螺旋聚合物的性能。随着时间的推移，观察到螺旋偏好的增加以及螺旋节距和单体交换动力学的减少。有人提出，手性单体的聚合物需要时间才能达到其最大的螺旋偏向偏好。