A temperature-sensitive hair dye was prepared with a poloxamer-sodium alginate mixture. When the hair dye was applied to the hair (< 32 °C), it retained its flow dynamics. The hair dye was able to undergo a phase change and formed a solid as soon as it touched the scalp (32°C), which reduced the transdermal amount of p-phenylenediamine (PPD) and also adverse effects and toxicity. Compared to a conventional hair dye, the temperature-sensitive hair dye achieved a reduction of the transdermal amount of p-phenylenediamine by almost 65% at different concentrations. At the same time, the colouring effect was not significantly reduced. The poloxamer alginate hydrogel can be used as a novel colouring material to reduce the harm of the dye intermediate to the human body when colouring hair.

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温度敏感型泊洛沙姆海藻酸钠凝胶减弱对苯二胺颜料的透皮作用

用泊洛沙姆-海藻酸钠混合物制备温度敏感染发剂。当染发剂涂在头发上时（< 32 °C），它保持了其流动动力学。染发剂一接触头皮（32°C）就会发生相变并形成固体，从而减少了透皮量p-苯二胺 (PPD) 以及副作用和毒性。与传统染发剂相比，感温染发剂实现了透皮量的减少。p-苯二胺在不同浓度下几乎减少了 65%。同时，着色效果也没有明显降低。海藻酸泊洛沙姆水凝胶可作为一种新型染发材料，在染发时减少染料中间体对人体的危害。