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Early communication development in infants and toddlers with Fragile X syndrome
Autism & Developmental Language Impairments Pub Date : 2022-05-06 , DOI: 10.1177/23969415221099403
Laura J Mattie 1 , Lisa R Hamrick 2
Affiliation  

Background and Aims

Individuals with fragile X syndrome (FXS) characteristically struggle with language and communication throughout the life course, but there is limited research on the development of communication before 24 months. The purpose of this study is to describe the early communication of infants and toddlers with FXS using the Communication and Symbolic Behavior Scales-Caregiver Questionnaire (CSBS-CQ), a standardized communication screening measure, as compared to the reported normative data of the CSBS-CQ and identify the percentage of infants and toddlers who scored within the range of concern. Documenting how children with FXS perform on screening measures can provide a quick snapshot of skills to help clinicians determine the need for services.

Methods

Participants were 22 infants and toddlers with FXS between 6 and 29 months. Performance on the CSBS-CQ was compared to the measure's normative data. The CSBS-CQ was completed by mothers, and children were administered the Mullen Scales of Early Learning. Because co-occurring autism is common in FXS, the presence of autism was determined using a clinical best estimate procedure.

Results

Overall and within the domains and subdomains of the CSBS-CQ, infants and toddlers with FXS had significantly lower scores than the normative data. Further, 68.2% of our sample was in the range of concern for their overall communication score. The presence of autism led to consistently lower scores, and more infants and toddlers with FXS + autism scored within the range of concern.

Conclusions

Our findings suggest that delays in early communication are evident in comparison to typically developing norms before 24 months. These findings also emphasize that infants and toddlers with FXS would likely benefit from early language intervention given that 68.2% of our sample was in the range of concern for their overall communication score.

Implications

Early identification and developmental monitoring of children with FXS will help to determine concerns in communication and other domains of development. While early communication broadly may not be an early indicator of autism in FXS, some specific skills, such as eye gaze, may serve as such an indicator. Screening measures, like the CSBS-CQ, may help monitor both early communication impairments and autism symptoms. Infants and toddlers with FXS, regardless of autism status, will benefit from early language interventions.



中文翻译:

患有脆性 X 综合征的婴幼儿的早期沟通发展

背景和目标

患有脆性 X 综合征 (FXS) 的个体在整个生命过程中都在语言和交流方面遇到困难,但对 24 个月之前交流发展的研究有限。本研究的目的是使用交流和象征行为量表-看护者问卷 (CSBS-CQ) 描述婴幼儿与 FXS 的早期交流,CSBS-CQ 是一种标准化的交流筛查措施,与报告的 CSBS 规范数据相比CQ 并确定得分在关注范围内的婴幼儿的百分比。记录患有 FXS 的儿童如何执行筛查措施可以提供技能的快速快照,以帮助临床医生确定服务需求。

方法

参与者是 22 名 6 至 29 个月大的 FXS 婴幼儿。将 CSBS-CQ 的表现与该措施的规范数据进行了比较。CSBS-CQ 由母亲完成,儿童接受 Mullen 早期学习量表。由于同时发生的自闭症在 FXS 中很常见,因此使用临床最佳估计程序确定自闭症的存在。

结果

总体而言,在 CSBS-CQ 的领域和子领域内,患有 FXS 的婴幼儿的得分明显低于正常数据。此外,我们的样本中有 68.2% 的人的整体沟通评分处于关注范围内。自闭症的存在导致得分持续较低,更多患有 FXS + 自闭症的婴幼儿得分在关注范围内。

结论

我们的研究结果表明,与通常在 24 个月前制定规范相比,早期沟通的延迟是显而易见的。这些发现还强调,鉴于我们的样本中 68.2% 的总体沟通评分处于关注范围内,患有 FXS 的婴幼儿可能会受益于早期语言干预。

启示

对患有 FXS 的儿童进行早期识别和发育监测将有助于确定沟通和其他发展领域的问题。虽然广泛的早期交流可能不是 FXS 自闭症的早期指标,但一些特定的技能,例如眼睛注视,可以作为这样的指标。筛查措施,如 CSBS-CQ,可能有助于监测早期沟通障碍和自闭症症状。患有 FXS 的婴幼儿,无论其自闭症状况如何,都将从早期语言干预中受益。

更新日期:2022-05-09
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