Cognitive dysfunction is a common adverse consequence of traumatic brain injury (TBI). After brain injury, the brain and other organs trigger a series of complex metabolic changes, including reduced glucose metabolism, enhanced lipid peroxidation, disordered neurotransmitter secretion, and imbalanced trace element synthesis. In recent years, several research and clinical studies have demonstrated that brain metabolism directly or indirectly affects cognitive dysfunction after TBI, but the mechanisms remain unclear. Drugs that improve the symptoms of cognitive dysfunction caused by TBI are under investigation and treatments that target metabolic processes are expected to improve cognitive function in the future. This review explores the impact of metabolic disorders on cognitive dysfunction after TBI and provides new strategies for the treatment of metabolic disorders.

认知功能障碍是创伤性脑损伤 (TBI) 的常见不良后果。脑损伤后，大脑和其他器官会引发一系列复杂的代谢变化，包括糖代谢降低、脂质过氧化增强、神经递质分泌紊乱、微量元素合成失衡等。近年来，多项研究和临床研究表明，脑代谢直接或间接影响TBI后的认知功能障碍，但机制尚不清楚。改善由 TBI 引起的认知功能障碍症状的药物正在研究中，针对代谢过程的治疗有望在未来改善认知功能。