Synergistic Pd/Cu Catalyzed Allylation of Cyclic Ketimine Esters with Vinylethylene Carbonates: Enantioselective Construction of Trisubstituted Allylic 2H-Pyrrole Derivatives.,Advanced Synthesis & Catalysis

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Synergistic Pd/Cu Catalyzed Allylation of Cyclic Ketimine Esters with Vinylethylene Carbonates: Enantioselective Construction of Trisubstituted Allylic 2H-Pyrrole Derivatives.
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2022-05-06 , DOI: 10.1002/adsc.202200416
M. Ke ₁ , Y. Yu ₁ , K. Zhang _{2,

3} , S. Zuo _{2,

3} , Z. Liu _{2,

3} , X. Xiao ₁ , F. Chen _{1,

2,

3}

Affiliation

The front cover image, provided by Fener Chen, illustrates an asymmetric allylation of cyclic ketimine esters with vinylethylene carbonates through a Pd/Cu dual catalysis system under a mild conditions. This protocol provides a range of trisubstituted allylic 2H-pyrrole analogues bearing a chiral tetrasubstituted stereogenic center in high yields and with excellent regioselectivities and enantioselectivities. A gram-scale operation was also conducted in high efficiency without erosion of enantioselectivity and stereoselectivity. Details can be found in the communication by Fener Chen and co-workers (M. Ke, Y. Yu, K. Zhang, S. Zuo, Z. Liu, X. Xiao, F. Chen, Adv. Synth. Catal. 2022, 364, XXXX–YYYY; DOI: 10.1002/adsc.202200039)

中文翻译：

环状酮亚胺酯与碳酸乙烯酯的协同 Pd/Cu 催化烯丙基化：三取代烯丙基 2H-吡咯衍生物的对映选择性构建。

封面图片由 Fener Chen 提供，展示了在温和条件下通过 Pd/Cu 双催化系统将环状酮亚胺酯与碳酸乙烯亚乙酯进行不对称烯丙基化。该协议提供了一系列三取代的烯丙基 2 H-吡咯类似物，具有高产率的手性四取代立体中心，并具有出色的区域选择性和对映选择性。还以高效率进行克级操作，而不会侵蚀对映选择性和立体选择性。详情可以在陈芬娜和同事的交流中找到（M. Ke, Y. Yu, K. Zhang, S. Zuo, Z. Liu, X. Xiao, F. Chen, Adv. Synth. Catal . 2022 , 364 , XXXX–YYYY; DOI: 10.1002/adsc.202200039)

更新日期：2022-05-06

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