E-cigarettes cause harm to adolescent users. The devices and constituents create multiple substances which are toxic on inhalation, including nicotine, metallic nanoparticles, particulate matter, and carbonyls. In addition, there is a robust relationship between youth vaping and use of combustible cigarettes as adults. This finding is based on longitudinal research and is found among youth who were at low risk for use of combustible cigarettes. Therefore, the most substantially confirmed health hazard of youth vaping is creating a new generation of smokers of combustible cigarettes and the documented health risks of such use. The physiological and psychological harms of nicotine dependence during adolescence also have been well documented. Additionally, population-based research has shown a consistent link between current vaping and respiratory issues during adolescence itself. Significant lung disease (EVALI) has occurred in adolescents and not all cases are linked to vitamin E acetate. Finally, extrapolating research on adults to adolescents raises the possibility that e-cigarette use is linked to pre-symptomatic cardiovascular dysfunction and may have a significant health impact during adulthood. The combination of this evidence, from pre-clinical to population-based longitudinal studies, conclusively demonstrates that e-cigarettes are not safe for youth.

电子烟对青少年使用者造成伤害。这些装置和成分会产生多种吸入有毒物质，包括尼古丁、金属纳米颗粒、颗粒物和羰基化合物。此外，青少年吸电子烟与成年后使用可燃香烟之间存在密切关系。这一发现基于纵向研究，发现于使用可燃香烟风险较低的青年中。因此，最充分确认的青少年吸电子烟对健康的危害是产生新一代可燃香烟的吸烟者，以及这种使用的记录在案的健康风险。青春期尼古丁依赖对生理和心理的危害也得到了充分的证明。此外，基于人群的研究表明，当前的电子烟与青春期本身的呼吸问题之间存在一致的联系。青少年发生了严重的肺部疾病（EVALI），并非所有病例都与维生素E醋酸盐。最后，将成年人的研究外推至青少年提出了电子烟使用与症状前心血管功能障碍有关的可能性，并可能对成年期的健康产生重大影响。从临床前到基于人群的纵向研究，这些证据的结合最终表明电子烟对青少年不安全。