Genetic and environmental factors during development are involved in autism, and in this issue of Neuron Krüttner et al. (2022) find environment may play a more acute role in modulating autism behavior in a Shank3 exon 21 deletion mutant mouse (Shank3^ΔC/ΔC). The authors explore the underlying circuit mechanisms in detail.

中文翻译：

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自闭症基因小鼠模型中的“似曾相识”改变了社会习俗

发育过程中的遗传和环境因素与自闭症有关，在本期 Neuron Krüttner 等人的文章中。(2022) 发现环境可能在调节Shank3外显子 21 缺失突变小鼠 ( Shank3 ^ΔC/ΔC )的自闭症行为中发挥更重要的作用。作者详细探讨了底层电路机制。