Embryoids and organoids hold great promise for human biology and medicine. Herein, we discuss conceptual and technological frameworks useful for developing high-fidelity embryoids and organoids that display tissue- and organ-level phenotypes and functions, which are critically needed for decoding developmental programs and improving translational applications. Through dissecting the layers of inputs controlling mammalian embryogenesis, we review recent progress in reconstructing multiscale structural orders in embryoids and organoids. Bioengineering tools useful for multiscale, multimodal structural engineering of tissue- and organ-level cellular organization and microenvironment are also discussed to present integrative, bioengineering-directed approaches to achieve next-generation, high-fidelity embryoids and organoids.

胚状体和类器官对人类生物学和医学有着广阔的前景。在此，我们讨论了可用于开发显示组织和器官水平表型和功能的高保真胚状体和类器官的概念和技术框架，这对于解码发育程序和改进转化应用至关重要。通过剖析控制哺乳动物胚胎发生的输入层，我们回顾了在类胚和类器官中重建多尺度结构顺序的最新进展。还讨论了可用于组织和器官级细胞组织和微环境的多尺度、多模态结构工程的生物工程工具，以提出综合的、生物工程导向的方法来实现下一代、高保真胚状体和类器官。