Bioactivity guided separation of Chukrasia velutina root methanolic extract led to the isolation of nine new isopimarane diterpenoids, chukranoids A–I (1–9). The absolute configuration was then assigned by comparing the experimental CD spectra and the calculated CD spectra. Chukranoids A–I (1–9) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. It seems that conjugate system in the isopimarane skeleton may influence their antimalarial activity.

Graphical abstract

中文翻译：

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Chukranoids A–I，来自 Chukrasia velutina 的异海藻烷二萜

Chukrasia velutina根甲醇提取物的生物活性引导分离导致九种新的异海藻烷二萜类化合物 chukranoids A–I (​​ 1 – 9 ) 的分离。然后通过比较实验 CD 光谱和计算的 CD 光谱来分配绝对构型。Chukranoids A–I (​​ 1 – 9 ) 对恶性疟原虫3D7 株表现出中等的抗疟活性。似乎 isopimarane 骨架中的共轭系统可能会影响它们的抗疟活性。

图形概要