Rapid and wide-ranging developments have established mechanochemistry as a powerful avenue in sustainable organic synthesis. This is primarily due to unique opportunities which have been offered in solvent-free – or highly solvent-minimised – reaction systems. Nevertheless, despite elegant advances in ball-milling technology, limitations in scale-up still remain. This tutorial review covers the first reports into the translation from “batch-mode” ball-milling to “flow-mode” reactive extrusion, using twin-screw extrusion.

中文翻译：

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连续流动机械化学：反应挤出作为有机合成中的使能技术

快速而广泛的发展已将机械化学确立为可持续有机合成的有力途径。这主要是由于无溶剂或高度减少溶剂的反应系统提供了独特的机会。尽管如此，尽管球磨技术取得了巨大的进步，但规模扩大的限制仍然存在。本教程回顾涵盖了使用双螺杆挤出从“批量模式”球磨转化为“流动模式”反应挤出的第一份报告。