Until now, the BDNF–TrkB signalling pathway was thought to be exclusively regulated by neurons. Ameroso et al. show that astrocytic TrkB.T1 is a critical substrate of BDNF in the regulation of energy balance and that its defective signalling in hypothalamic circuits leads to obesity.

中文翻译：

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饱腹感突触的星形胶质细胞清理

迄今为止，BDNF-TrkB 信号通路被认为仅受神经元调控。阿梅罗索等人。表明星形细胞 TrkB.T1 是 BDNF 在调节能量平衡中的关键底物，并且其在下丘脑回路中的缺陷信号传导会导致肥胖。