Proteins and peptides possess considerable potential in treating solid tumors because of their unique properties. At present, there are over 100 peptide-based formulations on the market. Today, peptides and proteins are in more demand due to their selective nature and high target-binding efficiency. Targeting solid tumors with compounds of molecular weight less than 10 kDa are much more desirable because they undergo excessive penetration in view of the fact that they are small sized. The solid tumors have thick tissues and possess excessive interstitial fluid pressure, because of which high molecular compounds cannot enter. The properties of proteins and peptides induce low toxic effects and lessen the major side effects caused by chemical-based drugs. However, their delivery is quite challenging as most proteins and peptides stop functioning therapeutically when following a parenteral route of administration. This paper elaborates on the importance of new age formulations of peptides and proteins followed by their recently documented advancements that increase their stability and delay their metabolism, which helps to target solid tumors.

中文翻译：

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通过蛋白质和肽药物递送 (PPD) 靶向实体瘤的智能进步

蛋白质和肽由于其独特的特性而在治疗实体瘤方面具有相当大的潜力。目前，市场上有超过 100 种基于肽的制剂。如今，肽和蛋白质因其选择性和高靶标结合效率而受到更多需求。用分子量小于 10 kDa 的化合物靶向实体瘤是更理想的，因为考虑到它们的体积小，它们会过度渗透。实体瘤组织厚，间质液压过高，高分子化合物无法进入。蛋白质和肽的特性诱导低毒性作用并减轻化学药物引起的主要副作用。然而，它们的递送非常具有挑战性，因为大多数蛋白质和肽在遵循肠胃外给药途径时会停止治疗功能。本文详细阐述了肽和蛋白质的新时代配方的重要性，以及它们最近记录的提高稳定性和延缓新陈代谢的进展，这有助于靶向实体瘤。