Three new pentacyclic triterpenes, trivially named sandkoetjapic acids A–C (1–3), have been isolated from the leaves extract of Sandoricum koetjape, along with the known triterpenes 3-oxo-olean-12-en-29-oic (4), bryonolic (5), and bryononic (6) acids. The structures of the new triterpenes were determined mainly by NMR spectroscopic and mass spectroscopic data. The isolation of these pentacyclic triterpenes in the plant’s leaves is for the first time. Preliminary biological evaluation of 1–6 was done against eight receptor tyrosine kinases (RTKs), including EGFR, HER2, HER4 (epidermal growth factor receptor), IGF1R, InsR (insulin receptor), KDR (kinase insert domain receptor), and PDGFRα/-β (platelet-derived growth factor receptor), and their inhibitory properties against β-lactamase. The results showed that none of them were active both as the inhibitors of these RTKs and β-lactamase.

从Sandoricum koetjape的叶子提取物中分离出三种新的五环三萜，俗称 Sandkoetjapic 酸 A-C ( 1-3 ) ，以及已知的三萜3 -oxo-olean-12-en-29-oic ( 4 ) 、 bryonolic ( 5 ) 和bryononic ( 6 ) 酸。新三萜的结构主要由核磁共振光谱和质谱数据确定。首次在植物叶片中分离出这些五环三萜。1 – 6的初步生物学评估针对八种受体酪氨酸激酶 (RTK)，包括 EGFR、HER2、HER4（表皮生长因子受体）、IGF1R、InsR（胰岛素受体）、KDR（激酶插入结构域受体）和 PDGFRα/-β（血小板衍生生长因子受体）及其对β-内酰胺酶的抑制特性。结果表明，它们都没有作为这些RTKs和β-内酰胺酶的抑制剂具有活性。