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Roles of vimentin in health and disease
Genes & Development ( IF 10.5 ) Pub Date : 2022-04-01 , DOI: 10.1101/gad.349358.122
Karen M Ridge 1, 2 , John E Eriksson 3, 4, 5 , Milos Pekny 6, 7, 8 , Robert D Goldman 1, 2
Affiliation  

More than 27 yr ago, the vimentin knockout (Vim−/−) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim−/− mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory responses. This review highlights the essential functions of vimentin IFs revealed from studies of Vim−/− mice and cells derived from them.

中文翻译:

波形蛋白在健康和疾病中的作用

27 多年前,据报道波形蛋白敲除 ( Vim −/− ) 小鼠在发育和繁殖时没有明显的表型,这意味着这种主要的细胞骨架蛋白不是必需的。随后,全面而仔细的分析揭示了Vim −/−小鼠及其器官、组织和细胞的多种表型,通常反映了各种损伤或损伤后组织恢复反应的改变。这些发现得到了基于细胞的实验的支持,表明波形蛋白中间丝 (IF) 在调节细胞力学中发挥着关键作用,并且需要协调机械传感、转导、信号通路、运动和炎症反应。这篇综述强调了对Vim −/−小鼠及其衍生细胞的研究揭示的波形蛋白 IF 的基本功能。
更新日期:2022-04-01
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