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Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-05-01 , DOI: 10.1039/d2lc00112h
Keisuke Oshimi 1, 2 , Yushi Nishimura 2, 3 , Tsutomu Matsubara 4 , Masuaki Tanaka 5 , Eiji Shikoh 5 , Li Zhao 6 , Yajuan Zou 1, 7 , Naoki Komatsu 7 , Yuta Ikado 1 , Yuka Takezawa 8 , Eriko Kage-Nakadai 8 , Yumi Izutsu 9 , Katsutoshi Yoshizato 10 , Saho Morita 11 , Masato Tokunaga 11 , Hiroshi Yukawa 3, 11, 12 , Yoshinobu Baba 3, 11, 12 , Yoshio Teki 2 , Masazumi Fujiwara 1, 2
Affiliation  

We report a notch-shaped coplanar microwave waveguide antenna on a glass plate designed for on-chip detection of optically detected magnetic resonance (ODMR) of fluorescent nanodiamonds (NDs). A lithographically patterned thin wire at the center of the notch area in the coplanar waveguide realizes a millimeter-scale ODMR detection area (1.5 × 2.0 mm2) and gigahertz-broadband characteristics with low reflection (∼8%). The ODMR signal intensity in the detection area is quantitatively predictable by numerical simulation. Using this chip device, we demonstrate a uniform ODMR signal intensity over the detection area for cells, tissue, and worms. The present demonstration of a chip-based microwave architecture will enable scalable chip integration of ODMR-based quantum sensing technology into various bioassay platforms.

中文翻译:

用于生物样品中的片上自旋检测的玻璃图案缺口型微波架构

我们报告了玻璃板上的凹口形共面微波波导天线,该天线设计用于对荧光纳米金刚石 (ND) 的光学检测磁共振 (ODMR) 进行片上检测。共面波导凹槽区域中心的光刻图案细线实现了毫米级 ODMR 检测区域 (1.5 × 2.0 mm 2)和具有低反射(~8%)的千兆赫宽带特性。检测区域中的 ODMR 信号强度可通过数值模拟进行定量预测。使用该芯片设备,我们在细胞、组织和蠕虫的检测区域展示了均匀的 ODMR 信号强度。目前基于芯片的微波架构的演示将使基于 ODMR 的量子传感技术的可扩展芯片集成到各种生物测定平台中。
更新日期:2022-05-05
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