Objectives

The effect of physical activity on hip/knee osteoarthritis (OA) and how it varies by genetic susceptibility to OA remains inconclusive.

Methods

In a cohort study of UK Biobank, 436,166 OA-free participants were recruited in 2006–2010 and followed for knee/hip OA until the end of 2020. 28 physical activity-related items were collected at baseline. Cox regression was used to estimate associations between physical activity behaviors, as well as major activity patterns (i.e., significant principal components[PCs] identified by principal component analysis), and risk of OA, adjusting for multiple confounders. We further stratified the analyses by polygenic risk score (PRS) for OA to examine the impact of genetic susceptibility to OA on the studied association.

Results

During a mean follow-up of 11.15 years, 13,227 hip and 21,119 knee OA cases were identified. 19, out of 28, studied items showed associations with increased OA risk. Compared with low adherence group(<1^st tertile of PC score for each pattern), individuals with high adherence to five identified patterns were associated with increased risk of OA. The moderate adherence to “strenuous sports”(HR = 0.93, 95%CI: 0.89–0.97) and “walking for pleasure”(HR = 0.93, 95%CI: 0.89–0.98) patterns was associated with reduced OA. Similar risk patterns were obtained in the stratified analysis by PRS levels for OA.

Conclusion

High intensity of most activity patterns were associated with increased OA. However, a protective effect was suggested for moderate adherence to patterns of “strenuous sports” and “walking for pleasure” that consistent across different genetic susceptibilities, underscoring the potential benefits of moderate-intensity physical activity on OA.

中文翻译：

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身体活动模式、遗传易感性和髋/膝骨关节炎风险：一项基于英国生物银行的前瞻性队列研究

目标

身体活动对髋/膝骨关节炎 (OA) 的影响以及它如何因 OA 遗传易感性而变化仍无定论。

方法

在 UK Biobank 的队列研究中，2006-2010 年招募了 436,166 名无 OA 参与者，并随访膝关节/髋关节 OA 直至 2020 年底。在基线时收集了 28 项与身体活动相关的项目。Cox 回归用于估计身体活动行为之间的关联，以及主要活动模式（即通过主成分分析确定的重要主成分 [PC]）和 OA 风险，调整多个混杂因素。我们通过 OA 的多基因风险评分 (PRS) 进一步对分析进行分层，以检查 OA 遗传易感性对研究关联的影响。

结果

在平均 11.15 年的随访期间，确定了 13,227 例髋关节和 21,119 例膝关节 OA 病例。在 28 个研究项目中，有 19 个项目显示与 OA 风险增加有关。与低依从性组（每种模式的 PC 评分均小于第 1^个三分位数）相比，对五种确定模式具有高依从性的个体与 OA 风险增加相关。适度坚持“剧烈运动”(HR = 0.93, 95%CI: 0.89-0.97) 和“为快乐而步行”(HR = 0.93, 95%CI: 0.89-0.98) 模式与 OA 减少相关。在按 OA 的 PRS 水平进行的分层分析中获得了类似的风险模式。

结论

大多数活动模式的高强度与 OA 增加有关。然而，对于适度坚持“剧烈运动”和“为乐趣而步行”的模式具有保护作用，这在不同的遗传易感性中是一致的，强调了中等强度的身体活动对 OA 的潜在益处。