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Beyond sole models for the first steps of Pt-DNA interactions: Fundamental properties of mono(nucleobase) adducts of PtII coordination compounds
Coordination Chemistry Reviews ( IF 20.6 ) Pub Date : 2022-04-29 , DOI: 10.1016/j.ccr.2022.214566
Bernhard Lippert 1 , Pablo J. Sanz Miguel 2
Affiliation  

A major feature of mono(nucleobase) complexes of PtII containing one or more aqua ligands is their ability to engage in intermolecular condensation reactions leading to multinuclear species with bridging nucleobases, bridging hydroxido or amido ligands. Their chemistry appears to be more versatile with isolated model nucleobases than is the case when relevant PtII species interact with nucleic acids. Special emphasis of this review article is on compounds obtained with pyrimidine model nucleobases (1-methylcytosine, 1-metylthymine, 1-methyluracil) and their cyclic condensation products. Aspects of chirality of mononuclear as well as head–tail dinuclear species will be discussed.



中文翻译:

超越 Pt-DNA 相互作用第一步的唯一模型:PtII 配位化合物的单(核碱基)加合物的基本性质

含有一个或多个水配体的 Pt II单(核碱基)配合物的一个主要特征是它们能够参与分子间缩合反应,从而产生具有桥接核碱基、桥接羟基或酰胺配体的多核物质。与相关的 Pt II物种与核酸相互作用的情况相比,它们的化学似乎更适用于分离的模型核碱基。这篇综述文章特别强调了用嘧啶模型核碱基(1-甲基胞嘧啶、1-甲基胸腺嘧啶、1-甲基尿嘧啶)获得的化合物及其环状缩合产物。将讨论单核和头尾双核物种的手性方面。

更新日期:2022-04-30
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